American Statistical Association
New York City
Metropolitan Area Chapter
April 4, 2016
The New York Metro Area Chapter of the American Statistical Association
In Collaboration With
The Educational Psychology Ph.D. Program of the City University of New York
Is Pleased to Invite You to a Colloquium On
STATISTICAL APPROACHES AND DECISION MAKING
IN NON-RANDOMIZED STUDIES
Knut M. Wittkowski, Ph.D., D.Sc.
Senior Research Associate, The Rockefeller University
Biometrician, The Rockefeller University Hospital
Director, Biostatistics/Epidemiology/Research Design
Center for Clinical and Translational Science (CCTS)
The clinical advances hoped for from genome-wide association studies (GWAS) have not yet materialized. Enlarging sample sizes to 10.000s limits the questions that can be addressed without guarding against non-functional SNPs differing between non-randomized populations.
To address the challenges specific to GWAS, one needs to:
(a) account for linkage disequilibrium (linkage disequilibrium), varying degrees of dominance, and compound heterozygocity across a moving window within the statistical method, and
(b) replace the conventional fixed 7.5 level with a study-specific cut-off for GW significance that accounts for differences in MAF, the non-randomized nature of GWAS, tests in overlapping diplotypes being related, and the lack of a traditional "nil-hypothesis" (genes have no impact).
With more appropriate methods and decision strategies, we can now identify collections of related genes in groups of 100s of subjects. The approach was validated by confirming the known targets of epilepsy drugs in 185 childhood cases:
Comparing non-verbal vs. verbal cases in the two independent stages of the Autism Genome project suggested a drug to prevent permanent disruption of language development.
Combined phase 2 data and subset phase 3 data can now be used to identify likely non-responders for subsequent studies.
Monday, April 4, 2016
4:30 to 6:15 P.M.
Doors open at 4:15 and talk begins at 4:30 P.M.
CUNY Graduate Center
365 Fifth Avenue (at 34th Street)
New York, New York
Registration and Fees
Seating is limited.
Advanced registration is required and there is no fee.
The registration deadline is Friday, April 1, 2016.
Please bring a photo ID for security reasons.
For questions, send an e-mail to firstname.lastname@example.org.
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