American Statistical Association
New York City
Metropolitan Area Chapter

Levin Lecture Series: Spring 2018 Colloquium Seminars
Department of Biostatistics
Columbia University



INTEGRATIVE DIRECTED CYCLIC GRAPHICAL MODELS WITH HETEROGENEOUS SAMPLES

by

Yang Ni, Postdoctoral Fellow
Department of Statistics and Data Sciences
University of Texas-Austin

Host: Dr. Jeff Goldsmith


Abstract

In this talk, I will introduce hierarchical directed cyclic graphical models to infer gene networks by integrating genomic data across platforms and across diseases. The proposed model takes into account tumor heterogeneity. In the case of data that can be naturally divided into known groups, we propose to connect graphs by introducing a hierarchical prior across group-specific graphs, including a correlation on edge strengths across graphs. A novel thresholding prior is applied to induce sparsity of the estimated networks and its connection to spike-and-slab prior and non-local prior will also be discussed. In the case of unknown groups, we cluster subjects into subpopulations and jointly estimate cluster-specific gene networks, again using similar hierarchical priors across clusters. Two applications with multiplatform genomic data for multiple cancers will be presented to illustrate the utility of our model.


Date: Monday, February 5, 2018
Time: 11:30 A.M. - 12:30 P.M.
Location: Mailman School of Public Health
Department of Biostatistics
722 West 168th Street
AR Building
Hess Commons
New York, New York

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