American Statistical Association
New York City
Metropolitan Area Chapter

The Levin Lecture Series
Department of Biostatistics Colloquium

Columbia University



Xihong Lin, Ph.D.
Department of Biostatistics
Harvard University

Host: Dr. Iuliana Ionita-Laza


Sequencing studies, such as targeted, whole exome and whole genome sequencing studies, are increasingly being conducted to identify rare variants that are associated with complex traits. Design and analysis of such population based sequencing association studies face many challenges. The talk has three parts. I will first provide an overview of several methods for studying rare variant effects, including burden tests, SKAT and optimal unified tests. Analysis pipelines for whole exome sequencing association studies, such as filtering criteria and small sample adjustments of statistical methods, will be discussed. In the second part of the talk, I will discuss designs of sequencing association studies, such as sample size and power calculations, and pros and cons of extreme phenotype sampling and analysis strategies for extreme phenotype sequencing studies. In the last part of the talk, I will discuss the performance of imputation using GWAS data for studying rare variants effects. Simulation studies and real data will be used to illustrate the results.

Biographical Note

Xihong Lin is Professor of Biostatistics and Coordinating Director of the Program in Quantitative Genomics at the Harvard School of Public Health. Her group's major research interests lie in development and application of statistical and computational methods for analysis of high-dimensional genomic and 'omics data in population and clinical sciences, and for analysis of correlated data, such as longitudinal, clustered and spatial data. They are interested in statistical genetics and genomics, genetic and epigenetic epidemiology, genes and environment and medical genomics. Current research projects include genome-wide association studies, next generation sequencing studies, gene-environment interactions, and genome-wide DNA methylation studies, pathway analysis and network analysis, proteomics.

Date: Thursday, April 5, 2012
Time: 3:30 - 4:30 P.M.
Location: Mailman School of Public Health
Department of Biostatistics
722 West 168th Street
Hess Commons
New York, New York


Informal tea at 3:15 P.M.

Home Page | Chapter News | Chapter Officers | Chapter Events
Other Metro Area Events | ASA National Home Page | Links To Other Websites
NYC ASA Chapter Constitution | NYC ASA Chapter By-Laws

Page last modified on March 31, 2012

Copyright © 1998-2012 by New York City Metropolitan Area Chapter of the ASA
Designed and maintained by Cynthia Scherer
Send questions or comments to