American Statistical Association
New York City
Metropolitan Area Chapter

Memorial Sloan-Kettering Cancer Center
Biostatistics Seminar

John Storey
Department of Molecular Biology
Princeton University


Over the course of several years, we have carried out an analysis of a large-scale study on 168 blunt-force trauma patients over 28 days, measuring ~400 clinical variables and longitudinal gene expression with ~800 microarrays. The aim of this study is to improve our ability to diagnose and treat inflammatory complications in critically injured patients. In this talk, I will describe the challenges we have faced in analyzing these data, and some of the methodological developments we have made in addressing these challenges. I will specifically discuss methods for dealing with latent structure in gene expression data and approaches for modeling the data in such a way that confounding sources of variation are eliminated. The advances we have made from this study will likely be applicable to future large-scale clinical genomics studies, and they have directly motivated more general developments we have made in large-scale inference methods.

Date: Wednesday, February 16, 2011
Time: 4:00 - 5:00 P.M.
Location: Memorial Sloan-Kettering Cancer Center
Department of Epidemiology and Biostatistics
307 East 63rd Street
(between First and Second Avenues)
3rd Floor Conference Room
New York, New York
Note: To gain access to the building, please follow the directions by the telephone in the foyer.


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