American Statistical Association
Energy and small molecules are cultivated and re-packaged to make new proteins, organelles, and cells through a diverse set of processes that we call metabolism. Studying the operation of metabolic processes, how they have evolved over time, and how they have gone awry in disease, is inherently tied to what kinds of measurements we can make of metabolism. In this talk, we will take a spin in the medium-data world of metabolism, where missing data is prevalent, observations are inaccurate, and historical errors propagate through decades. I will (try to) talk about the evolution of allosteric enzyme regulation, the reprogramming of metabolism in tumor initiation and progression, and the incidence of apparently growth-impairing mitochondrial mutations in cancers. To do so, I will draw on ideas from thermodynamics, sequence analysis, and informatics, hopefully leaving you with the impression that metabolism is by turns frustrating and fascinating.
|Date:||Wednesday, February 21, 2018|
|Time:||4:00 - 5:00 P.M.|
Memorial Sloan Kettering Cancer Center
Department of Epidemiology and Biostatistics
485 Lexington Avenue
(Between 46th & 47th Streets)
2nd Floor, Conference Room B
New York, New York
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