American Statistical Association
New York City
Metropolitan Area Chapter

Memorial Sloan-Kettering Cancer Center
Biostatistics Seminar

Melissa J. Fazzari, Ph.D.
Assistant Professor
Department of Epidemiology and Population Health
Albert Einstein College of Medicine


Epigenomics is a rapidly emerging field that involves the study of changes in the regulation of gene activity that are not dependent on gene sequence. In this talk, I will provide an overview of the two main types epigenetic modification: methylation, a repressive epigenetic mark on DNA, and histone modification, a post translational modification of histone tails. Altered methylation has been shown to play a role in oncogene activation, psychiatric disorders and autism. The patterns of methylation, gene expression and histone modification at gene promoters will be explored. I will also present an analysis of the predictors of imprinting, another epigenetic phenomenon caused by preferential methylation. It is assumed that there are many undiscovered imprinted genes in the human genome; therefore, prioritization of candidate genes may allow for a more efficient way to search for imprinted genes on a genome-wide basis.

Date: Wednesday, February 27, 2008
Time: 4:00 P.M. - 5:00 P.M.
Location: Memorial Sloan-Kettering Cancer Center
Department of Epidemiology and Biostatistics
307 East 63rd Street
(between First and Second Avenues)
3rd Floor Conference Room
New York, New York
Note: To gain access to the building, please follow the directions by the telephone in the foyer.


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