American Statistical Association
New York City
Metropolitan Area Chapter

Memorial Sloan-Kettering Cancer Center
Biostatistics Seminar

Giovanni Parmigiani
Department of Biostatistics
Harvard University


The purpose of cancer genome sequencing studies is to determine the nature and types of alterations present in a typical cancer and to discover genes mutated at high frequencies. In the earlier of these studies to investigate the whole genome, about 20 thousand genes were sequenced, using a two-stage design where all genes were sequenced on a discovery set of samples, and then those in which at least one alteration was found were sequenced in an additional validation sample. The two-stage sampling, the rarity of mutations, the varied size and composition of genes, all contribute to generating an interesting and unusual testing ground for statistical methodologies. In this lecture, I will present some of the statistical challenges that arise in these studies, with special emphasis on multiple testing and gene set analysis.

Date: Wednesday, March 16, 2011
Time: 4:00 - 5:00 P.M.
Location: Memorial Sloan-Kettering Cancer Center
Department of Epidemiology and Biostatistics
307 East 63rd Street
(between First and Second Avenues)
Room 331
New York, New York
Note: To gain access to the building, please follow the directions by the telephone in the foyer.


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