American Statistical Association
New York City
Metropolitan Area Chapter

Memorial Sloan-Kettering Cancer Center
Biostatistics Seminar

Zhigang Zhang
Department of Epidemiology & Biostatistics
Memorial Sloan-Kettering Cancer Center


In statistical analysis, when the value of a random variable is only known to be between two bounds, we say that this random variable is interval censored. This complicated censoring pattern is a common problem in research fields such as clinical trials or actuarial studies and raises challenges for statistical analysis. In this paper, we focus on regression analysis of case 2 interval-censored data. We first briefly review existing regression methods and an estimation approach under the class of linear transformation models developed by Zhang et al. (2005). We then propose a method for survival probability prediction via generalized estimating equations. We also consider a graphical model checking technique and a model selection tool. Some theoretical properties are established and the performance of our procedures is evaluated and illustrated by numerical studies including a real-life data analysis.

Date: Wednesday, September 15, 2010
Time: 4:00 - 5:00 P.M.
Location: Memorial Sloan-Kettering Cancer Center
Department of Epidemiology and Biostatistics
307 East 63rd Street
(between First and Second Avenues)
Room 331
New York, New York
Note: To gain access to the building, please follow the directions by the telephone in the foyer.


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