American Statistical Association
New York City
Metropolitan Area Chapter

Memorial Sloan-Kettering Cancer Center
Biostatistics Seminar

This seminar is RESCHEDULED for tomorrow,
Thursday, October 28, 2010
due to air traffic challenges.

Ewout Steyerberg
Department of Public Health
Erasmus MC - University Medical Center Rotterdam, Netherlands


Prognostic models are increasingly being published in medical journals. Interest in prognosis and prediction is growing by the increase in knowledge on biomarkers, genomics, and better imaging. Prognostic models combine a number of characteristics of a subject to predict an outcome, for example an underlying diagnosis or a prognostic event such as mortality. Multivariable regression models are often used.

In this talk, I will discuss several types of prognostic research questions, starting with:

I will focus on the use of external information in prognostic research. Specifically, I will consider the situation where published literature presents information on prognostic factors in an aggregated way (univariate regression coefficients) and how we might incorporate such external knowledge in a prognostic model. Various approaches will be considered, extending previous work.1

1. Steyerberg EW, Eijkemans MJ, Van Houwelingen JC, Lee KL, Habbema JD. Prognostic models based on literature and individual patient data in logistic regression analysis. Stat Med 2000; 19:141-60.

Date: Wednesday, October 27, 2010 - RESCHEDULED for Thursday, October 28, 2010
Time: 11:00 A.M. - 12:00 P.M. - Please note time change.
Location: Memorial Sloan-Kettering Cancer Center
Department of Epidemiology and Biostatistics
307 East 63rd Street
(between First and Second Avenues)
Room 331
New York, New York
Note: To gain access to the building, please follow the directions by the telephone in the foyer.


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