American Statistical Association
New York City
Metropolitan Area Chapter

New York State Psychiatric Institute
at Columbia University Medical Center
Biostatistics Seminar



Jeanne A. Teresi, Ed.D, Ph.D.
Senior Research Scientist, NYSPI;
Columbia University Stroud Center and Faculty of Medicine;
Administrator and Director, Research Division, Hebrew Home at Riverdale


The Patient Reported Outcomes Information System (PROMIS) is an NIH roadmap initiative that aims to provide an infrastructure for clinicians and researchers by establishing generic item banks across various disease groups, and applications of computerized adaptive testing (CAT). This initiative is designed to stimulate and standardize clinical research measurement across NIH programs and grants dealing with patient-reported outcomes. The Statistical Coordinating Center is performing item response theory, item banking and CAT. One domain addressed by PROMIS is emotional distress, including measurement of depression.

Surveys that assess latent traits or states such as attitudes, affect, and health often use scales in order to increase the likelihood of robust measurement. Conceptual and psychometric measurement equivalence of such scales is a basic requirement for valid group comparisons. The construction of a valid item bank and accompanying short form measures is dependent on the quality of the items. Differential item functioning (DIF) analysis is commonly used to examine the measurement equivalence of items in scales.

Presented in this talk will be the (a) overall structure of PROMIS, (b) construction of the depression item bank, (c) qualitative and quantitative psychometric evaluation of the items, including DIF analyses, (d) the draft short forms, and (e) CAT applications associated with the bank.

Biographical Note

Dr. Jeanne Teresi is a senior research scientist at the New York State Psychiatric Institute, a member of the Columbia University Stroud Center, Faculty of Medicine, and Administrator and Director of the Research Division of the Hebrew Home at Riverdale. Her doctorates are in gerontology and measurement and statistics. Her areas of expertise include measurement, health disparities and long-term care. She has written extensively in the area of differential item functioning using item response theory. She has been an associate editor of Biometrics, and has served on the editorial board of several journals, including The Gerontologist and Psychology and Aging. She is currently a deputy editor of Medical Care. She has been the co-editor of several volumes related to measurement, and most recently was the senior editor of a special issue of Medical Care devoted to qualitative and quantitative methods for use in examining the performance of measures.

Date: Tuesday, January 27, 2009
Time: 3:00 - 4:00 P.M.
Location: New York State Psychiatric Institute
1051 Riverside Drive
6th Floor Multipurpose Room (6602)
New York, New York


Coffee: 2:45 to 3:00 P.M.
Reception: 4:00 to 4:30 P.M.

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